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Clinical Trials

The Department of Surgery doesn’t just excel in the operating room. Through our extensive and innovative research programs, we are also focused on the development of new techniques and therapies that promote better outcomes and improve the quality of life for patients following surgery. 

As part of that goal, the department’s surgeons are involved in groundbreaking clinical trials. In addition to their research value, clinical trials may also give patients access to new treatments that are not available anywhere else.

Learn more about our current clinical trials below or visit the Joint Clinical Trials Office at Weill Cornell Medicine and NewYork-Presbyterian.

This clinical trial is for men and women diagnosed with ischemic heart disease (myocardial ischemia) who are eligible to be treated with coronary angioplasty (PCI).

This clinical trial is for men and women age 18 and older with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). 

Key Inclusion / Exclusion Criteria:
  • Women and men age 18 and older. 
  • Pathologically confirmed diagnosis of Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) 
  • Have received at least one prior therapy for CLL/SLL 
  • Detailed eligibility reviewed when you contact the study team. 

The primary purpose of the Study is to compare the safety, tolerability and effectivenss of ruxolitinib with that of anagrelide in patients with essential thrombocythemia (ET) who are resistant or intolerant to Hydroxyurea. 

Key Inclusion / Exclusion Criteria:
  • Subjects must be 18 or older 
  • Subject must have a diagnosis of essential thrombocythemia 
  • Subjects must be intolerant or resistant to Hydroxyurea 
  • Subject must not have been previously treated with anagrelide or JAK inhibitors 
  • Detailed eligibility will be reviewed when you contact the study team 

This is a phase II, multi-center study to determine the efficacy and safety of first-line CC-486 plus CHOP in patients with Peripheral T-cell Lymphoma (PTCL) who have received no prior systemic therapy.

Key Inclusion / Exclusion Criteria:

   • Women and men age 18 and older with histologically confirmed diagnosis of Peripheral T-cell Lymphoma 
   • No prior systemic therapy for lymphoma 
   • Detailed eligibility reviewed when you contact the study team

Video of A Phase II Study of CC486-CHOP in Previously Untreated Peripheral T-cell Lymphoma

This research study is for pregnant women who have either Crohn’s disease or ulcerative colitis.

Key Inclusion / Exclusion Criteria:
  • Pregnant women with Crohn's disease or ulcerative colitis
  • Age 18 to 50

This trial is open to women and men age 55 and older with active, relapsed or refractory acute myeloid leukemia (AML).

Key Inclusion / Exclusion Criteria:
  • Women and men age 55 and older 
  • Have active, relapsed or refractory AML 
  • Detailed eligibility reviewed when you contact the study team 

This clinical trial is for men and women age 18 and older with previously treated CLL/SLL, MCL, FL, MZL, DLBCL, or RTL. Relapsed or refractory hematological cancers are serious, disabling, and life-threatening disorders.

Key Inclusion / Exclusion Criteria:
  • Men and women age 18 and older 
  • Histologically confirmed diagnosis of CLL/SLL, MCL, FL, MZL, DLBCL, or RTL 
  • Hematological cancer has been previously treated and has progressed during or relapsed after prior systemic therapy. 
  • Detailed eligibility reviewed when you contact the study team. 

    

This clinical trial is a Phase 1 study evaluating the safety of LAM-003 when administered to men and women with previously treated relapsed or refractory AML. Currently, there is a great unmet need for treating AML that has either not responded to or returned after other treatments.

Key Inclusion / Exclusion Criteria:
  • The study is open to men and women aged 18 years or older with a diagnosis of acute myeloid leukemia (AML). 
  • Subjects’ AML must have been previously treated and has progressed during or relapsed after prior therapy. 
  • Detailed eligibility will be reviewed by the study team. 

This clinical trial is for men and women with high-grade gliomas that has recurred for the first time. There is currently a need for more effective treatment methods for this disease. 

Key Inclusion / Exclusion Criteria:
  • Open to men and women above the age of 18 who have been diagnosed with high-grade gliomas 
  • Histologically confirmed diagnosis of IDH-mutant high-grade (III or IV) glioma 
  • First recurrence of glioma 
  • Detailed eligibility will be reviewed when you contact the study team 

This is a phase 1, open-label, first-in-human (FIH) study designed to evaluate the safety, tolerability, effectiveness of BLU-667 administered orally in patients.

Key Inclusion / Exclusion Criteria:
  • Open to women and men age 18 and older 
  • Diagnosis pathologically documented, definitively diagnosed as non-resectable advanced solid tumor (e.g. thyroid, non small cell lung, colon) 
  • Patient must have non-resectable disease that has progressed following standard therapy or has not adequately responded to standard therapy, or the patient must be intolerant to available standard therapies, or there must be no accepted standard therapy for their disease
  • Detailed eligibility reviewed when you contact the study team

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